After developing flu-like symptoms, the disease can result in a number of other complications, such as weight loss, fatigue, or shortness of breath. In some cases, loss of vision can occur, and if it spreads to the central nervous system it could result in seizures. Diagnosing signs of histoplasmosis often involves the use of chest x-rays or in extreme cases CT scans.

The infection is not always guaranteed to be fatal; sometimes it will clear on its own, and it can be treated with antifungal medication. However, there is no vaccine against histoplasmosis. Fortunately, histoplasmosis is not contagious. But with its ability to become airborne, bat guano can easily spread it to an entire household, including any visitors, making it nonetheless a very dangerous disease that needs to be controlled.

As a result, when tackling a bat guano problem, it is vital that a respirator facemask is worn to avoid inhaling any spores, as well as a fully disposable safety suit to avoid physical contact with it. When removing bat guano, it is recommended to spray water over the contaminated site to stop the dust from spreading when disturbed, making it easier to get rid of.

This can then be vacuumed up or bagged and then taken to a landfill site, although it may require an industrial vacuum such as those used by professionals. Whilst loose bat guano should be removed, it may be necessary to also replace loft insulation and thoroughly clean and disinfect surfaces to kill off any remaining spores using bleach. Lastly, the attic should be inspected and any breaches sealed to stop another infestation from occurring.