While the rules regarding poisoning animals vary from state to state, there is one notable factor regarding skunk poison- there are no legal and verified poisons designed for poisoning skunks. This creates one very significant issue- any poisons you use on a skunk could create a long, drawn-out, painful death for the skunk. In fact, the poison may not even kill the skunk at all. Instead, it could just create a painful experience for the skunk and injure it internally. Poisoning isn’t a good way to get rid of an animal infestation, as it’s an inhumane method and can be ineffective in many situations.